Everything about Protamine Sulfate totally explained
Protamine sulfate is a drug that reverses the
anticoagulant effects of
heparin by binding to it.
Protamine was formerly isolated from the sperm of various fish, but is now produced through
recombinant biotechnology. It is a highly
cationic peptide. It binds to heparin to form a stable ion pair which doesn't have anticoagulant activity. This complex is then removed and broken down by the
reticuloendothelial system.
Dosage
Dosage for heparin reversal is 1mg protamine sulfate i.v. for every 100 IU of active heparin. It causes significant
histamine release resulting in
hypotension and
bronchoconstriction, and also causes
pulmonary hypertension. Infusion should be slow to minimize these side effects. In large doses, protamine itself has some anticoagulant effect.
Uses
Protamine sulfate is usually administered to reverse the large dose of heparin administered during certain surgeries, especially
heart surgery. It is also used in gene transfer and protein purification.
Further Information
Get more info on 'Protamine Sulfate'.
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